HEPH

Across TCGA pan-cancer cohorts, HEPH mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HEPH’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where HEPH mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types HEPH is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

PDAC, COAD, and HNSC are the cancer types where HEPH tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HEPH mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	IV	+1.113	<.001	10	view →
COAD	Female	III,IV	−0.383	<.001	9	view →
HNSC	Male	All	+0.236	.008	4	view →
LUAD	Female	All	−0.252	.008	3	view →
CCRCC	Male	III,IV	−0.278	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

HEPH–PDAC

Open the PDAC breakdown →