HEPACAM

Across TCGA patient cohorts, HEPACAM mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEPACAM-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and EGFR. Each is linked with HEPACAM in more than 1 cancer types. Because this analysis shows association rather than direction, both HEPACAM-to-partner and partner-to-HEPACAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by HEPACAM-low versus HEPACAM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEPACAM→partner) and Y-score (partner→HEPACAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.194	+2.459	.008	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.584	+1.736	.004	.007	3	2
UCEC	EGFR →	-0.150	-2.433	.006	.018	3	1
UCEC	eIF4G →	+0.227	+1.874	.034	.049	3	1
UCEC	FoxM1 →	+0.208	+2.070	.020	.001	3	1
UCEC	GAPDH →	+0.419	+1.874	.024	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

eIF4E by HEPACAM expression — UCEC

Explore this box plot interactively →