HEPACAM

Across TCGA cell cohorts, HEPACAM mutation is significantly associated with the mutation status of many other genes, with 382 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEPACAM-associated genes across cancer lineages are OR2D3, ZNF267, and ZSCAN25. Each is linked with HEPACAM in more than 1 cancer types. Because this analysis shows association rather than direction, both HEPACAM-to-partner and partner-to-HEPACAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2D3 grouped by HEPACAM-low versus HEPACAM-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEPACAM→partner) and Y-score (partner→HEPACAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2D3 →	+4.772	+5.339	.004	.004	1	2
LARGE_INTESTINE	ZNF267 →	+2.459	+3.321	.005	.005	1	2
LARGE_INTESTINE	ZSCAN25 →	+3.459	+3.459	.006	.006	1	2
LARGE_INTESTINE	VRTN →	+2.459	+3.321	.005	.005	1	2
BLOOD_Leukemia	MAPK8IP1 →	+4.560	+4.309	.007	.007	1	2
BLOOD_Leukemia	DCAF1 →	+4.560	+4.309	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 382 associations by consensus.

OR2D3 by HEPACAM expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →