HEMGN

Across TCGA pan-cancer cohorts, HEMGN mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of HEMGN’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where HEMGN mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types HEMGN is over-expressed in tumor, although a few such as PDAC and LSCC show the opposite, repressed pattern.

LUAD, PDAC, and LSCC are the cancer types where HEMGN tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HEMGN mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	+0.550	.040	2	view →
PDAC	Female	All	−0.457	.013	2	view →
LSCC	Female	II,III,IV	−0.245	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

HEMGN–LUAD

Open the LUAD breakdown →