HELZ2

Across TCGA patient cohorts, HELZ2 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. COAD shows the largest number of these associations.

The most reproducible HELZ2-associated genes across cancer lineages are TIGAR, c-Jun_pS73, and c-Kit. Each is linked with HELZ2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HELZ2-to-partner and partner-to-HELZ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by HELZ2-low versus HELZ2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELZ2→partner) and Y-score (partner→HELZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TIGAR →	+0.326	+1.686	.017	.013	3	3
UCEC	c-Jun_pS73 →	-0.102	-1.838	.030	.007	3	3
UCEC	c-Kit →	-0.185	-1.986	.007	.008	3	3
BLCA	MSH6 →	+0.323	+3.169	.046	.018	3	2
LUAD	TFRC →	+0.592	+2.321	.018	.035	3	2
LUAD	Caveolin-1 →	-0.857	-2.321	.013	.035	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

TIGAR by HELZ2 expression — COAD

Explore this box plot interactively →