HELZ2

Across TCGA cell cohorts, HELZ2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,487 significant associations in total. CNS shows the largest number of these associations.

The most reproducible HELZ2-associated GO terms across cancer lineages are Defense response to virus, Cellular response to chemical stress, and Interferon-mediated signaling pathway. Each is linked with HELZ2 in more than 17 cancer types. Because this analysis shows association rather than direction, both HELZ2-to-partner and partner-to-HELZ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Defense response to virus grouped by HELZ2-low versus HELZ2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HELZ2→partner) and Y-score (partner→HELZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Defense response to virus →	+0.099	+1.887	<.001	<.001	3	18
BONE	Cellular response to chemical stress →	+0.055	+1.568	<.001	.002	3	18
OESOPHAGUS	Interferon-mediated signaling pathway →	+0.157	+2.212	<.001	<.001	3	17
URINARY_TRACT	Regulation of interferon-beta production →	+0.080	+1.041	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Response to starvation →	+0.053	+2.101	<.001	<.001	3	17
OVARY	Positive regulation of canonical NF-kappaB signal transduction →	+0.061	+1.184	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,487 associations by consensus.

Defense response to virus by HELZ2 expression — BREAST

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