HELZ2

Across TCGA cell cohorts, HELZ2 mutation is significantly associated with the RNA expression of many other genes, with 2,463 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HELZ2-associated genes across cancer lineages are ACYP1, OTX1, and NLRP6. Each is linked with HELZ2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HELZ2-to-partner and partner-to-HELZ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACYP1 grouped by HELZ2-low versus HELZ2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELZ2→partner) and Y-score (partner→HELZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACYP1 →	+0.390	+3.459	.009	<.001	3	4
LARGE_INTESTINE	OTX1 →	+0.541	+2.115	.002	.004	3	3
URINARY_TRACT	NLRP6 →	+0.073	+2.807	.001	.003	3	3
LARGE_INTESTINE	FEM1A →	+0.714	+2.364	<.001	<.001	3	3
LARGE_INTESTINE	POMGNT2 →	+0.701	+2.115	<.001	.004	3	3
LARGE_INTESTINE	CCNO →	+0.825	+2.321	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,463 associations by consensus.

ACYP1 by HELZ2 expression — LARGE_INTESTINE

Explore this box plot interactively →