Across TCGA pan-cancer cohorts, HELZ Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HELZ data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HELZ Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated HELZ expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, KICH, and UCS are the cancer types where HELZ Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.827	0.620	.001	32	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
UCS	OS	Median	All	0.185	0.686	.034	6	view →
PRAD	DFS	Median	All	0.085	0.774	.006	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
LUSC	OS	Median	All	1.000	0.668	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: HELZ tumor-vs-normal RNA expression · all HELZ data types