Across TCGA pan-cancer cohorts, HELZ mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HELZ data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HELZ mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HELZ expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where HELZ mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.872	0.597	<.001	30	view →
PDAC	OS	Median	III,IV	0.537	1.000	.008	15	view →
UCEC	DFS	Tertile	III,IV	0.880	0.350	.013	12	view →
LUAD	DFS	Median	All	1.000	0.419	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: HELZ tumor-vs-normal RNA expression · all HELZ data types