Across TCGA patient cohorts, HELZ RNA expression is significantly associated with the protein abundance of many other proteins, with 10,252 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HELZ-associated proteins across cancer lineages are RPL26, RPS6_S240, and BPTF. Each is linked with HELZ in more than 4 cancer types. Because this analysis shows association rather than direction, both HELZ-to-partner and partner-to-HELZ results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HELZ→partner) and Y-score (partner→HELZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPL26 →	-0.523	-0.394	<.001	<.001	3	5
LSCC	RPS6_S240 →	-0.831	-0.367	<.001	.003	3	4
HNSC	BPTF →	+0.229	+0.695	<.001	.004	3	4
LSCC	EFTUD2 →	+0.173	+0.320	<.001	<.001	3	4
GBM	HDGFL2 →	+0.336	+0.285	.001	<.001	3	4
GBM	HNRNPLL →	+0.261	+0.374	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,252 associations by consensus.

Exploration

HELZ survival (RNA) · tumor vs normal (RNA) · all HELZ data types