Across TCGA patient cohorts, HELZ protein abundance is significantly associated with the RNA expression of many other genes, with 6,756 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HELZ-associated genes across cancer lineages are PSMD12, KPNA2, and PHYHIP. Each is linked with HELZ in more than 4 cancer types. Because this analysis shows association rather than direction, both HELZ-to-partner and partner-to-HELZ results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELZ→partner) and Y-score (partner→HELZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PSMD12 →	+0.458	+0.168	.002	.006	3	5
BRCA	KPNA2 →	+0.819	+0.167	<.001	<.001	3	4
GBM	PHYHIP →	-1.199	-0.197	.001	.004	3	4
BRCA	ANKMY2 →	-0.471	-0.149	<.001	<.001	3	3
GBM	MAPK8IP1 →	-0.712	-0.244	.001	<.001	3	3
BRCA	METTL2A →	+0.577	+0.197	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,756 associations by consensus.

Exploration

HELZ survival (RNA) · tumor vs normal (RNA) · all HELZ data types