Across TCGA patient cohorts, HELZ mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HELZ-associated genes across cancer lineages are ASNS, p38-MAPK_pT180_Y182, and FASN. Each is linked with HELZ in more than 5 cancer types. Because this analysis shows association rather than direction, both HELZ-to-partner and partner-to-HELZ results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELZ→partner) and Y-score (partner→HELZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.565	+2.815	.009	.036	2	6
UCEC	p38-MAPK_pT180_Y182 →	-0.256	-0.947	.019	.042	3	3
STAD	FASN →	+0.646	+3.015	.001	.018	3	2
BLCA	IGFBP2 →	-0.353	-2.222	.017	.010	3	2
COAD	C-Raf →	+0.176	+2.815	.028	.036	3	2
UCEC	eIF4E →	+0.153	+2.261	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Exploration

HELZ survival (RNA) · tumor vs normal (RNA) · all HELZ data types