Across TCGA cell cohorts, HELZ RNA expression is significantly associated with the go_rna of many other GO terms, with 4,296 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HELZ-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Negative regulation of gene expression, epigenetic, and Heterochromatin formation. Each is linked with HELZ in more than 17 cancer types. Because this analysis shows association rather than direction, both HELZ-to-partner and partner-to-HELZ results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HELZ→partner) and Y-score (partner→HELZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Epigenetic regulation of gene expression →	+0.081	+0.700	<.001	<.001	3	18
BONE	Negative regulation of gene expression, epigenetic →	+0.101	+0.784	<.001	<.001	3	18
BONE	Heterochromatin formation →	+0.098	+0.802	<.001	<.001	3	17
STOMACH	Positive regulation of mRNA catabolic process →	+0.075	+1.159	.001	.003	3	17
BONE	Heterochromatin organization →	+0.096	+0.806	<.001	<.001	3	17
BLOOD_Lymphoma	Negative regulation of chromosome condensation →	+0.166	+1.210	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,296 associations by consensus.

Exploration

HELZ survival (RNA) · tumor vs normal (RNA) · all HELZ data types