Across TCGA cell cohorts, HELZ mutation is significantly associated with the RNA expression of many other genes, with 106 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HELZ-associated genes across cancer lineages are CGB8, CCT8L2, and CRYBA1. Each is linked with HELZ in more than 1 cancer types. Because this analysis shows association rather than direction, both HELZ-to-partner and partner-to-HELZ results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELZ→partner) and Y-score (partner→HELZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CGB8 →	+1.221	+3.256	<.001	.005	3	2
BLOOD_Leukemia	CCT8L2 →	+0.009	+3.289	<.001	.009	3	2
BREAST	CRYBA1 →	+0.091	+3.762	.006	.003	3	2
BLOOD_Myeloma	UGT2A3 →	+0.007	+2.459	.001	.003	3	1
BLOOD_Myeloma	CCIN →	+0.031	+2.222	.008	.008	3	1
BLOOD_Myeloma	MS4A4E →	+0.063	+2.392	.004	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

Exploration

HELZ survival (RNA) · tumor vs normal (RNA) · all HELZ data types