Across TCGA patient cohorts, HELT mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HELT-associated genes across cancer lineages are Tuberin_pT1462, p27_pT157, and Akt_pS473. Each is linked with HELT in more than 1 cancer types. Because this analysis shows association rather than direction, both HELT-to-partner and partner-to-HELT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELT→partner) and Y-score (partner→HELT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin_pT1462 →	+0.301	+2.179	.005	.034	3	2
UCEC	p27_pT157 →	-0.069	-2.282	.010	.034	3	1
UCEC	Akt_pS473 →	+0.802	+2.321	.016	.034	3	1
UCEC	Tuberin →	+0.404	+3.179	.001	.010	3	1
UCEC	YB-1 →	+0.180	+2.999	.015	.035	3	1
UCEC	ERK2 →	+0.226	+3.169	.012	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

HELT survival (RNA) · tumor vs normal (RNA) · all HELT data types