Across TCGA cell cohorts, HELT mutation is significantly associated with the drug of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HELT-associated genes across cancer lineages are AGI-6780, Teniposide, and 50869. Each is linked with HELT in more than 1 cancer types. Because this analysis shows association rather than direction, both HELT-to-partner and partner-to-HELT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELT→partner) and Y-score (partner→HELT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AGI-6780 →	+0.419	+2.646	.030	.047	3	1
LARGE_INTESTINE	Teniposide →	+0.602	+2.649	.023	.046	3	1
LARGE_INTESTINE	50869 →	+0.479	+2.649	.023	.046	3	1
LARGE_INTESTINE	720427 →	+0.261	+2.649	.049	.046	3	1
LARGE_INTESTINE	eEF2K Inhibitor →	+0.263	+2.652	.017	.045	3	1
LARGE_INTESTINE	Niraparib →	+0.358	+2.646	.045	.047	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

HELT survival (RNA) · tumor vs normal (RNA) · all HELT data types