HELQ

Across TCGA pan-cancer cohorts, HELQ mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HELQ data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HELQ mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HELQ expression acts as an unfavorable survival marker.

LUAD, LSCC, and CCRCC are the cancer types where HELQ mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.148	1.000	.045	6	view →
LSCC	DFS	Tertile	II,III,IV	0.557	1.000	.020	5	view →
CCRCC	OS	Median	All	0.685	1.000	.015	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HELQ–LUAD (OS)

Open the LUAD breakdown →