HELQ

Across TCGA patient cohorts, HELQ RNA expression is significantly associated with the protein abundance of many other proteins, with 14,094 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HELQ-associated proteins across cancer lineages are PPIF, PSMD5, and RPS8. Each is linked with HELQ in more than 4 cancer types. Because this analysis shows association rather than direction, both HELQ-to-partner and partner-to-HELQ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HELQ versus PPIF in CCRCC, with a Pearson correlation of -0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HELQ→partner) and Y-score (partner→HELQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PPIF →	-0.431	-0.328	<.001	<.001	3	5
BRCA	PSMD5 →	+0.311	+0.345	<.001	.003	3	5
LUAD	RPS8 →	-0.252	-0.234	<.001	<.001	3	5
CCRCC	ADH5 →	+0.350	+0.386	<.001	<.001	3	5
PDAC	ENOPH1 →	+0.393	+0.333	<.001	<.001	3	5
GBM	KIF1B_S1487 →	-0.390	-0.251	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,094 associations by consensus.

HELQ vs PPIF — CCRCC

Explore this scatter interactively →