HELQ

Across TCGA patient cohorts, HELQ protein abundance is significantly associated with the RNA expression of many other genes, with 4,280 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HELQ-associated genes across cancer lineages are KIF13A, CXCL8, and ZNF540. Each is linked with HELQ in more than 2 cancer types. Because this analysis shows association rather than direction, both HELQ-to-partner and partner-to-HELQ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HELQ versus KIF13A in LUAD, with a Pearson correlation of -0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELQ→partner) and Y-score (partner→HELQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KIF13A →	-0.903	-1.751	.006	<.001	3	3
LUAD	CXCL8 →	+2.639	+1.309	.002	.002	3	3
LUAD	ZNF540 →	-0.947	-1.471	<.001	.001	3	3
LUAD	ZNF25 →	-0.647	-1.167	.002	.001	3	3
GBM	NAP1L3 →	-1.173	-0.406	<.001	<.001	3	3
GBM	ARMCX3 →	-0.651	-0.424	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,280 associations by consensus.

HELQ vs KIF13A — LUAD

Explore this scatter interactively →