HELQ

Across TCGA patient cohorts, HELQ mutation is significantly associated with the RNA expression of many other genes, with 2,779 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HELQ-associated genes across cancer lineages are BUB3, H2AZ1, and GLOD4. Each is linked with HELQ in more than 2 cancer types. Because this analysis shows association rather than direction, both HELQ-to-partner and partner-to-HELQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by HELQ-low versus HELQ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELQ→partner) and Y-score (partner→HELQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.429	+1.703	<.001	.006	3	3
UCEC	H2AZ1 →	+0.577	+1.925	<.001	<.001	3	3
UCEC	GLOD4 →	+0.473	+1.903	<.001	<.001	3	3
UCEC	HINT1 →	+0.492	+2.628	<.001	<.001	3	3
UCEC	TMEM126A →	+0.315	+2.376	.001	.002	3	3
UCEC	MAP2K4 →	+0.393	+3.010	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,779 associations by consensus.

BUB3 by HELQ expression — UCEC

Explore this box plot interactively →