HELQ

Across TCGA patient cohorts, HELQ mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HELQ-associated genes across cancer lineages are ATM, PCNA, and MEK1. Each is linked with HELQ in more than 3 cancer types. Because this analysis shows association rather than direction, both HELQ-to-partner and partner-to-HELQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HELQ-low versus HELQ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELQ→partner) and Y-score (partner→HELQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.582	-2.687	<.001	.005	3	4
UCEC	PCNA →	+0.235	+2.415	.002	.003	3	3
UCEC	MEK1 →	+0.463	+3.087	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.383	-1.990	<.001	.009	3	2
UCEC	Di-Ras3 →	-0.121	-2.308	.023	.033	3	2
LUSC	EGFR →	+0.736	+3.009	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ATM by HELQ expression — UCEC

Explore this box plot interactively →