HELQ

Across TCGA cell cohorts, HELQ RNA expression is significantly associated with the go_rna of many other GO terms, with 3,643 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HELQ-associated GO terms across cancer lineages are DNA double-strand break processing, Double-strand break repair via nonhomologous end joining, and DNA double-strand break processing involved in repair via single-strand annealing. Each is linked with HELQ in more than 14 cancer types. Because this analysis shows association rather than direction, both HELQ-to-partner and partner-to-HELQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA double-strand break processing grouped by HELQ-low versus HELQ-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HELQ→partner) and Y-score (partner→HELQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA double-strand break processing →	+0.105	+0.947	<.001	<.001	3	15
SOFT_TISSUE	Double-strand break repair via nonhomologous end joining →	+0.060	+0.913	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA double-strand break processing involved in repair via single-strand annealing →	+0.102	+0.918	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Double-strand break repair via single-strand annealing →	+0.102	+0.918	<.001	<.001	3	13
BREAST	Positive regulation of organelle assembly →	+0.062	+0.793	<.001	<.001	2	13
URINARY_TRACT	Double-strand break repair via synthesis-dependent strand annealing →	+0.080	+0.639	<.001	.005	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,643 associations by consensus.

DNA double-strand break processing by HELQ expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →