HELQ

Across TCGA cell cohorts, HELQ mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HELQ-associated genes across cancer lineages are FAM71B, LCE1D, and KRT28. Each is linked with HELQ in more than 1 cancer types. Because this analysis shows association rather than direction, both HELQ-to-partner and partner-to-HELQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71B grouped by HELQ-low versus HELQ-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELQ→partner) and Y-score (partner→HELQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FAM71B →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	LCE1D →	+0.206	+4.906	<.001	.006	3	1
OESOPHAGUS	KRT28 →	+0.016	+4.906	<.001	.006	3	1
OESOPHAGUS	SLC5A8 →	+0.070	+4.906	<.001	.006	3	1
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
SOFT_TISSUE	BHLHA9 →	+0.036	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

FAM71B by HELQ expression — OESOPHAGUS

Explore this box plot interactively →