HELB

Across TCGA pan-cancer cohorts, HELB mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HELB data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HELB mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated HELB expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and PDAC are the cancer types where HELB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.979	0.496	.023	5	view →
LUAD	DFS	Median	All	0.737	0.336	.026	4	view →
PDAC	DFS	Tertile	II,III,IV	0.515	0.861	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HELB–LSCC (DFS)

Open the LSCC breakdown →