HELB

Across TCGA patient cohorts, HELB protein abundance is significantly associated with the RNA expression of many other genes, with 2,492 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HELB-associated genes across cancer lineages are TRAPPC2P2, ZMYND10, and CCNJ. Each is linked with HELB in more than 1 cancer types. Because this analysis shows association rather than direction, both HELB-to-partner and partner-to-HELB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HELB versus TRAPPC2P2 in HNSC, with a Pearson correlation of -0.76.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELB→partner) and Y-score (partner→HELB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRAPPC2P2 →	-1.057	-0.664	.007	.002	3	2
BRCA	ZMYND10 →	-1.490	-0.390	.003	.007	3	2
OV	CCNJ →	+0.946	+1.363	.005	.002	3	2
UCEC	ZNF90 →	+1.438	+0.732	.006	.003	3	2
UCEC	MPZL2 →	-1.704	-0.882	.004	.002	3	2
UCEC	CCDC125 →	-0.754	-0.600	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,492 associations by consensus.

HELB vs TRAPPC2P2 — HNSC

Explore this scatter interactively →