HELB

Across TCGA patient cohorts, HELB mutation is significantly associated with the RNA expression of many other genes, with 2,673 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HELB-associated genes across cancer lineages are ZNF232-AS1, RACGAP1, and MELK. Each is linked with HELB in more than 2 cancer types. Because this analysis shows association rather than direction, both HELB-to-partner and partner-to-HELB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF232-AS1 grouped by HELB-low versus HELB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELB→partner) and Y-score (partner→HELB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZNF232-AS1 →	+0.726	+3.352	<.001	.005	3	3
UCEC	RACGAP1 →	+0.516	+1.684	.002	.006	3	3
UCEC	MELK →	+0.603	+2.673	.001	<.001	3	3
UCEC	PCLAF →	+0.668	+2.078	<.001	<.001	3	3
UCEC	GLOD4 →	+0.434	+2.332	<.001	<.001	3	3
COAD	TSR1 →	+0.476	+3.220	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,673 associations by consensus.

ZNF232-AS1 by HELB expression — COAD

Explore this box plot interactively →