HELB

Across TCGA patient cohorts, HELB mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HELB-associated genes across cancer lineages are p62 Lck ligand, p27_pT157, and TIGAR. Each is linked with HELB in more than 2 cancer types. Because this analysis shows association rather than direction, both HELB-to-partner and partner-to-HELB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by HELB-low versus HELB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELB→partner) and Y-score (partner→HELB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.368	+3.087	<.001	<.001	3	3
UCEC	p27_pT157 →	-0.054	-1.415	.002	.010	3	2
UCEC	TIGAR →	+0.094	+1.228	.048	.018	3	2
UCEC	ASNS →	+0.369	+1.765	<.001	.013	3	2
UCEC	Chk2_pT68 →	-0.167	-2.295	.003	.005	3	2
UCEC	Cyclin-B1 →	+0.619	+1.893	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

p62 Lck ligand by HELB expression — UCEC

Explore this box plot interactively →