HELB

Across TCGA cell cohorts, HELB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,209 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HELB-associated GO terms across cancer lineages are Establishment of RNA localization, Regulation of mRNA catabolic process, and RNA catabolic process. Each is linked with HELB in more than 14 cancer types. Because this analysis shows association rather than direction, both HELB-to-partner and partner-to-HELB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of RNA localization grouped by HELB-low versus HELB-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HELB→partner) and Y-score (partner→HELB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Establishment of RNA localization →	+0.117	+0.525	<.001	<.001	3	15
PANCREAS	Regulation of mRNA catabolic process →	+0.055	+0.426	<.001	.004	3	15
OVARY	RNA catabolic process →	+0.060	+0.550	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	RNA localization →	+0.107	+0.590	<.001	<.001	3	15
OVARY	DNA biosynthetic process →	+0.057	+0.606	<.001	<.001	3	15
BONE	Regulation of protein localization to Cajal body →	+0.093	+0.471	.004	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,209 associations by consensus.

Establishment of RNA localization by HELB expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →