HELB

Across TCGA cell cohorts, HELB mutation is significantly associated with the RNA expression of many other genes, with 710 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HELB-associated genes across cancer lineages are KSR2, C10orf53, and CYP7A1. Each is linked with HELB in more than 1 cancer types. Because this analysis shows association rather than direction, both HELB-to-partner and partner-to-HELB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KSR2 grouped by HELB-low versus HELB-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HELB→partner) and Y-score (partner→HELB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KSR2 →	+0.396	+2.502	.004	.005	3	2
LARGE_INTESTINE	C10orf53 →	+0.007	+2.462	.003	.004	3	2
BLOOD_Lymphoma	CYP7A1 →	+0.017	+4.191	<.001	.007	3	2
PANCREAS	DPPA4 →	+0.018	+4.222	<.001	.002	3	1
PANCREAS	NLGN4Y →	+0.723	+4.039	<.001	.003	3	1
PANCREAS	NEUROG1 →	+0.026	+4.029	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 710 associations by consensus.

KSR2 by HELB expression — LARGE_INTESTINE

Explore this box plot interactively →