HEG1

Across TCGA pan-cancer cohorts, HEG1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HEG1 data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher HEG1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HEG1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KICH, UCEC, and LGG are the cancer types where HEG1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	All	0.161	0.881	<.001	24	view →
UCEC	DFS	Median	All	0.957	0.825	.010	24	view →
LGG	DFS	Median	All	0.325	0.757	.018	8	view →
LIHC	DFS	Median	All	0.195	0.545	.040	3	view →
SKCM	DFS	Median	III,IV	0.063	0.648	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HEG1–KICH (OS)

Open the KICH breakdown →