HEG1

Across TCGA patient cohorts, HEG1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,631 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HEG1-associated genes across cancer lineages are GPR176, CD93, and CDH11. Each is linked with HEG1 in more than 6 cancer types. Because this analysis shows association rather than direction, both HEG1-to-partner and partner-to-HEG1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HEG1 versus GPR176 in OV, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEG1→partner) and Y-score (partner→HEG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GPR176 →	+1.285	+0.756	<.001	<.001	3	7
BRCA	CD93 →	+1.087	+1.085	<.001	<.001	3	6
BRCA	CDH11 →	+1.236	+0.723	<.001	<.001	3	6
OV	TAGLN →	+1.070	+0.436	<.001	<.001	3	6
OV	LATS2 →	+0.822	+0.639	<.001	<.001	3	6
CCRCC	TAL1 →	+1.022	+0.462	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,631 associations by consensus.

HEG1 vs GPR176 — OV

Explore this scatter interactively →