HEG1

Across TCGA patient cohorts, HEG1 mutation is significantly associated with the RNA expression of many other genes, with 3,666 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEG1-associated genes across cancer lineages are MIR625, MIR520C, and RBMX2. Each is linked with HEG1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HEG1-to-partner and partner-to-HEG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR625 grouped by HEG1-low versus HEG1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEG1→partner) and Y-score (partner→HEG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR625 →	+0.550	+6.276	<.001	<.001	3	4
SKCM	MIR520C →	+0.131	+2.965	<.001	.008	3	4
BLCA	RBMX2 →	+0.457	+3.213	.002	.009	3	3
CESC	RNU1-14P →	+0.205	+4.539	<.001	.001	3	3
UCEC	RNU1-17P →	+0.137	+1.765	<.001	.003	3	3
UCEC	WDR41 →	+0.281	+2.098	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,666 associations by consensus.

MIR625 by HEG1 expression — READ

Explore this box plot interactively →