HEG1

Across TCGA patient cohorts, HEG1 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HEG1-associated genes across cancer lineages are PRDX1, STAT3_pY705, and Stathmin. Each is linked with HEG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HEG1-to-partner and partner-to-HEG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by HEG1-low versus HEG1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEG1→partner) and Y-score (partner→HEG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PRDX1 →	+0.394	+2.820	<.001	.035	3	3
UCEC	STAT3_pY705 →	-0.316	-1.263	<.001	.019	3	3
COAD	Stathmin →	+0.198	+2.178	.006	.035	3	3
SKCM	4E-BP1_pT70 →	+0.220	+3.339	.018	.005	3	3
UCEC	Caspase-7-cleavedD198 →	+0.551	+2.090	.002	<.001	3	3
BLCA	JNK2 →	-0.289	-2.987	.001	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

PRDX1 by HEG1 expression — BLCA

Explore this box plot interactively →