HEG1

Across TCGA cell cohorts, HEG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,470 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HEG1-associated GO terms across cancer lineages are Negative regulation of Rho protein signal transduction, Wound healing, and Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Each is linked with HEG1 in more than 15 cancer types. Because this analysis shows association rather than direction, both HEG1-to-partner and partner-to-HEG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Rho protein signal transduction grouped by HEG1-low versus HEG1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HEG1→partner) and Y-score (partner→HEG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of Rho protein signal transduction →	+0.187	+3.305	<.001	<.001	3	16
BONE	Wound healing →	+0.136	+3.238	<.001	<.001	3	15
BONE	Positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.090	+2.726	<.001	<.001	3	15
BONE	Regulation of cell-substrate adhesion →	+0.130	+2.583	<.001	<.001	3	15
BONE	Regulation of plasminogen activation →	+0.285	+3.848	<.001	<.001	3	14
BONE	Peptidyl-lysine oxidation →	+1.399	+3.283	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,470 associations by consensus.

Negative regulation of Rho protein signal transduction by HEG1 expression — BONE

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