HEG1

Across TCGA cell cohorts, HEG1 mutation is significantly associated with the RNA expression of many other genes, with 438 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HEG1-associated genes across cancer lineages are OR52L1, OR6B2, and LRRC74A. Each is linked with HEG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HEG1-to-partner and partner-to-HEG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52L1 grouped by HEG1-low versus HEG1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HEG1→partner) and Y-score (partner→HEG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR52L1 →	+0.095	+3.947	<.001	.004	3	2
LARGE_INTESTINE	OR6B2 →	+0.021	+1.691	<.001	.009	3	2
BLOOD_Myeloma	LRRC74A →	+0.013	+4.807	<.001	.006	3	1
SKIN	OR5M11 →	+0.057	+4.437	<.001	.004	3	1
SKIN	HNRNPCL3 →	+0.050	+4.054	<.001	.004	3	1
LUNG_SCLC	TEX26 →	+0.097	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 438 associations by consensus.

OR52L1 by HEG1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →