HECW2

Across TCGA pan-cancer cohorts, HECW2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HECW2 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher HECW2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated HECW2 expression acts as an unfavorable survival marker, although some lineages such as GBM and LUAD show a favorable association.

LSCC, GBM, and LUAD are the cancer types where HECW2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.591	1.000	.004	17	view →
GBM	DFS	Tertile	All	0.859	0.654	.003	8	view →
LUAD	OS	Tertile	III,IV	1.000	0.753	.010	3	view →
CCRCC	OS	Quartile	All	1.000	0.731	.017	3	view →
HNSC	OS	Quartile	III,IV	1.000	0.817	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HECW2–LSCC (DFS)

Open the LSCC breakdown →