HECW2

Across TCGA patient cohorts, HECW2 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HECW2-associated genes across cancer lineages are TFRC, GAPDH, and PCNA. Each is linked with HECW2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HECW2-to-partner and partner-to-HECW2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by HECW2-low versus HECW2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECW2→partner) and Y-score (partner→HECW2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TFRC →	+0.746	+3.700	.001	.001	3	3
COAD	GAPDH →	+0.444	+1.882	.036	.031	3	3
COAD	PCNA →	+0.244	+2.820	.018	.035	3	3
UCEC	PKC-delta_pS664 →	-0.069	-1.321	.026	.024	3	3
UCEC	PDCD4 →	-0.380	-1.440	.001	.020	3	2
LUAD	Caveolin-1 →	-1.157	-3.700	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

TFRC by HECW2 expression — LUAD

Explore this box plot interactively →