HECW2

Across TCGA cell cohorts, HECW2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,911 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HECW2-associated GO terms across cancer lineages are Regulation of cellular response to transforming growth factor beta stimulus, Establishment of epithelial cell apical/basal polarity, and Protein secretion. Each is linked with HECW2 in more than 9 cancer types. Because this analysis shows association rather than direction, both HECW2-to-partner and partner-to-HECW2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cellular response to transforming growth factor beta stimulus grouped by HECW2-low versus HECW2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HECW2→partner) and Y-score (partner→HECW2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cellular response to transforming growth factor beta stimulus →	+0.081	+1.325	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Establishment of epithelial cell apical/basal polarity →	+0.234	+0.914	<.001	<.001	3	9
STOMACH	Protein secretion →	+0.073	+1.135	<.001	.006	3	9
BONE	Regulation of transforming growth factor beta receptor signaling pathway →	+0.078	+1.333	<.001	<.001	3	9
BONE	Positive regulation of actin filament bundle assembly →	+0.202	+1.521	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Golgi to plasma membrane transport →	+0.100	+1.381	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,911 associations by consensus.

Regulation of cellular response to transforming growth factor beta stimulus by HECW2 expression — BONE

Explore this box plot interactively →