HECW2

Across TCGA cell cohorts, HECW2 mutation is significantly associated with the RNA expression of many other genes, with 2,212 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HECW2-associated genes across cancer lineages are PANK4, SGSM3, and SETD7. Each is linked with HECW2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HECW2-to-partner and partner-to-HECW2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PANK4 grouped by HECW2-low versus HECW2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECW2→partner) and Y-score (partner→HECW2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PANK4 →	+0.636	+3.120	.002	.009	3	3
LARGE_INTESTINE	SGSM3 →	+0.657	+2.628	.002	.002	3	3
LARGE_INTESTINE	SETD7 →	+0.722	+2.628	.001	.002	3	3
SOFT_TISSUE	OR4X2 →	+0.018	+5.369	.001	.004	3	2
SOFT_TISSUE	OR1C1 →	+0.105	+4.930	<.001	.008	3	2
PANCREAS	ZNF716 →	+0.094	+4.491	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,212 associations by consensus.

PANK4 by HECW2 expression — BLOOD_Leukemia

Explore this box plot interactively →