HECTD2

Across TCGA patient cohorts, HECTD2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HECTD2-associated genes across cancer lineages are ATM, FASN, and ASNS. Each is linked with HECTD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HECTD2-to-partner and partner-to-HECTD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HECTD2-low versus HECTD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD2→partner) and Y-score (partner→HECTD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.472	-1.777	.001	.002	3	3
UCEC	FASN →	+0.285	+1.678	.023	.021	3	2
UCEC	ASNS →	+0.356	+1.584	.002	.017	3	2
UCEC	Cyclin-B1 →	+0.709	+2.999	<.001	<.001	3	2
UCEC	eEF2 →	+0.320	+1.765	.005	.013	3	1
UCEC	eIF4E →	+0.147	+3.472	.029	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ATM by HECTD2 expression — UCEC

Explore this box plot interactively →