HECTD2

Across TCGA cell cohorts, HECTD2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HECTD2-associated genes across cancer lineages are PRORY, DCD, and CRYGC. Each is linked with HECTD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both HECTD2-to-partner and partner-to-HECTD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRORY grouped by HECTD2-low versus HECTD2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD2→partner) and Y-score (partner→HECTD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	PRORY →	+0.536	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	DCD →	+0.046	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CRYGC →	+0.083	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	RPS4Y2 →	+0.080	+4.643	<.001	.008	3	1
CNS	KRTAP5-6 →	+0.052	+4.832	<.001	.002	3	1
CNS	MEIKIN →	+0.069	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PRORY by HECTD2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →