HECTD2

Across TCGA cell cohorts, HECTD2 mutation is significantly associated with the mutation status of many other genes, with 1,192 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HECTD2-associated genes across cancer lineages are MEGF10, CLEC3A, and WDR6. Each is linked with HECTD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HECTD2-to-partner and partner-to-HECTD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEGF10 grouped by HECTD2-low versus HECTD2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD2→partner) and Y-score (partner→HECTD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MEGF10 →	+3.584	+4.922	.001	.001	1	4
BLOOD_Lymphoma	CLEC3A →	+4.584	+4.584	.007	.007	1	3
BLOOD_Lymphoma	WDR6 →	+4.169	+5.316	<.001	<.001	1	3
BLOOD_Leukemia	TRMT12 →	+4.894	+4.894	.004	.004	1	3
BLOOD_Leukemia	ATXN2 →	+3.672	+5.083	.001	.001	1	3
LARGE_INTESTINE	DUOX1 →	+2.321	+2.643	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,192 associations by consensus.

MEGF10 by HECTD2 expression — BLOOD_Lymphoma

Explore this box plot interactively →