HECTD1

Across TCGA pan-cancer cohorts, HECTD1 Mutation is linked to patient survival in 15 of 34 cancer types, making it a survival-associated HECTD1 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher HECTD1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HECTD1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

DLBC, HNSC, and LUAD are the cancer types where HECTD1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Median	II,III,IV	0.172	0.949	<.001	30	view →
HNSC	OS	Median	III,IV	0.222	0.665	<.001	15	view →
LUAD	OS	Median	III,IV	0.158	0.663	.008	14	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
KIRP	OS	Median	II,III,IV	0.188	0.771	.016	12	view →
LUSC	OS	Median	II,III,IV	0.211	0.620	.006	9	view →
PCPG	DFS	Median	All	0.070	0.936	<.001	6	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
SCLC	OS	Median	All	0.247	0.658	.007	6	view →
BRCA	OS	Median	III,IV	0.609	0.906	.026	6	view →
PRAD	DFS	Median	All	0.617	0.886	.038	6	view →
STAD	OS	Median	III,IV	0.184	0.641	.011	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

HECTD1–DLBC (OS)

Open the DLBC breakdown →