HECTD1

Across TCGA pan-cancer cohorts, HECTD1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HECTD1 data layer compared with 26 for mass-spec protein and 15 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HECTD1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HECTD1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where HECTD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.725	0.953	<.001	45	view →
PDAC	OS	Median	IV	0.381	0.951	.006	24	view →
HNSC	OS	Quartile	IV	0.891	0.605	.016	3	view →
UCEC	OS	Median	All	0.982	0.917	.043	2	view →
LSCC	OS	Median	All	0.793	1.000	.017	2	view →
LUAD	DFS	Median	All	0.936	0.869	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HECTD1–CCRCC (OS)

Open the CCRCC breakdown →