HECTD1

Across TCGA patient cohorts, HECTD1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,686 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible HECTD1-associated genes across cancer lineages are NTRK2, WDR35, and TGFBI. Each is linked with HECTD1 in more than 5 cancer types. Because this analysis shows association rather than direction, both HECTD1-to-partner and partner-to-HECTD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HECTD1 versus NTRK2 in LSCC, with a Pearson correlation of -0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD1→partner) and Y-score (partner→HECTD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NTRK2 →	-2.352	-0.162	<.001	<.001	3	6
HNSC	WDR35 →	-0.686	-0.351	.001	<.001	3	5
CCRCC	TGFBI →	+1.495	+0.113	.006	.009	3	5
OV	EMILIN1 →	+1.204	+0.246	.003	.002	3	5
CCRCC	TMEM92 →	+1.187	+0.142	<.001	.002	3	5
LSCC	TMEM45A →	+0.985	+0.154	.001	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,686 associations by consensus.

HECTD1 vs NTRK2 — LSCC

Explore this scatter interactively →