HECTD1

Across TCGA patient cohorts, HECTD1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HECTD1-associated genes across cancer lineages are ATM, PRAS40_pT246, and Cyclin-E2. Each is linked with HECTD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HECTD1-to-partner and partner-to-HECTD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HECTD1-low versus HECTD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD1→partner) and Y-score (partner→HECTD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.491	-1.632	<.001	<.001	3	4
BLCA	PRAS40_pT246 →	+0.113	+1.700	.033	.043	3	3
BLCA	Cyclin-E2 →	+0.197	+1.700	.004	.043	3	3
COAD	ERK2 →	+0.190	+3.000	.046	.035	3	3
UCEC	MEK1 →	+0.419	+2.044	<.001	<.001	3	3
SKCM	p90 RSK →	+0.204	+2.222	.021	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

ATM by HECTD1 expression — UCEC

Explore this box plot interactively →