HECTD1

Across TCGA cell cohorts, HECTD1 mutation is significantly associated with the RNA expression of many other genes, with 1,726 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HECTD1-associated genes across cancer lineages are GPR101, CENPM, and TRMU. Each is linked with HECTD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HECTD1-to-partner and partner-to-HECTD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR101 grouped by HECTD1-low versus HECTD1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECTD1→partner) and Y-score (partner→HECTD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GPR101 →	+0.019	+3.990	<.001	.003	3	2
LARGE_INTESTINE	CENPM →	+0.687	+3.584	<.001	<.001	3	2
LARGE_INTESTINE	TRMU →	+0.578	+2.700	<.001	<.001	3	2
LARGE_INTESTINE	ALKBH1 →	+0.317	+3.321	.004	.002	3	2
LARGE_INTESTINE	ZC3H14 →	+0.541	+2.212	<.001	<.001	3	2
LARGE_INTESTINE	CCNP →	+1.143	+1.808	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,726 associations by consensus.

GPR101 by HECTD1 expression — OVARY

Explore this box plot interactively →