HECA

Across TCGA pan-cancer cohorts, HECA mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of HECA’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where HECA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types HECA is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, CCRCC, and COAD are the cancer types where HECA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HECA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−0.244	<.001	9	view →
CCRCC	All	All	+0.171	<.001	7	view →
COAD	All	All	−0.210	.011	4	view →
HNSC	All	III,IV	−0.131	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

HECA–LUAD

Open the LUAD breakdown →