HECA

Across TCGA patient cohorts, HECA protein abundance is significantly associated with the RNA expression of many other genes, with 13,248 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HECA-associated genes across cancer lineages are KLF12, KPNA5, and HMCN1. Each is linked with HECA in more than 5 cancer types. Because this analysis shows association rather than direction, both HECA-to-partner and partner-to-HECA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HECA versus KLF12 in UCEC, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HECA→partner) and Y-score (partner→HECA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KLF12 →	+0.891	+0.193	.008	.002	3	6
GBM	KPNA5 →	+0.529	+0.272	<.001	<.001	3	5
UCEC	HMCN1 →	+0.846	+0.193	.001	.001	3	5
GBM	PLCL1 →	+0.868	+0.189	<.001	.007	3	5
CCRCC	CNRIP1 →	+0.750	+0.214	<.001	<.001	3	5
GBM	PDGFRA →	+1.536	+0.193	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,248 associations by consensus.

HECA vs KLF12 — UCEC

Explore this scatter interactively →