HECA

Across TCGA patient cohorts, HECA protein abundance is significantly associated with the protein abundance of many other proteins, with 21,375 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible HECA-associated proteins across cancer lineages are HDGFL3, UNK, and LMNB2. Each is linked with HECA in more than 7 cancer types. Because this analysis shows association rather than direction, both HECA-to-partner and partner-to-HECA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HECA versus HDGFL3 in UCEC, with a Pearson correlation of 0.52.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HECA→partner) and Y-score (partner→HECA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HDGFL3 →	+0.660	+0.197	<.001	<.001	3	6
OV	UNK →	+0.258	+0.265	<.001	.002	1	8
UCEC	LMNB2 →	+0.423	+0.297	<.001	<.001	3	6
UCEC	AGO1 →	+0.365	+0.206	<.001	<.001	3	5
LSCC	ARID1B →	+0.249	+0.214	<.001	.001	3	5
LUAD	PEAK1_T1165 →	+0.715	+0.196	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,375 associations by consensus.

HECA vs HDGFL3 — UCEC

Explore this scatter interactively →